Synthetic method for erlotinib intermediate
The invention relates to a synthetic method for a erlotinib intermediate 6,7-di(2-methoxy ethyoxyl) quinazoline-4-ketone. The synthetic method comprises the following steps: in the presence of an ammonia gas, reacting 2-amino-4,5-di(2-methoxy ethyoxyl) ethyl benzoate or an acid salt thereof with for...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention relates to a synthetic method for a erlotinib intermediate 6,7-di(2-methoxy ethyoxyl) quinazoline-4-ketone. The synthetic method comprises the following steps: in the presence of an ammonia gas, reacting 2-amino-4,5-di(2-methoxy ethyoxyl) ethyl benzoate or an acid salt thereof with formamide to obtain 6,7-di(2-methoxy ethyoxyl) quinazoline-4-ketone. The synthetic method has the advantages of high reaction selectivity and a high raw material utilization rate. |
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