Method for separating and detecting CETP (Cholesteryl Ester Transfer Protein) inhibitor

Method for separating and detecting CETP (Cholesteryl Ester Transfer Protein) inhibitor

The invention discloses a method for separating and detecting Anacetrapib and isomers of Anacetrapib. According to the method, with a CHIRALPAK AD-H Chiral chromatographic column (250P*4.6mm) serving as a separating chromatographic column, and n-hexane: isopropanol=95:5(V/V) serving as a mobile phas...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WEN JINGBING, RAO WANBING, YAO LIHUA, LIU RUIJUAN, LIU GUOZHU, LU LINGCHUN
Format: Patent
Sprache:chi ; eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:The invention discloses a method for separating and detecting Anacetrapib and isomers of Anacetrapib. According to the method, with a CHIRALPAK AD-H Chiral chromatographic column (250P*4.6mm) serving as a separating chromatographic column, and n-hexane: isopropanol=95:5(V/V) serving as a mobile phase, the baseline separation of Anacetrapib from three optical isomers of Anacetrapib can be achieved, so that the content of isomer impurities and diastereoisomers of Anacetrapib can be effectively controlled. The method is capable of simply, rapidly and accurately separating and detecting Anacetrapib and the optical isomers of Anacetrapib.