Preparation method of dexrazoxane

The invention relates to a preparation method of dexrazoxane. In allusion to various problems of a present dexrazoxane synthetic route, such as complexity, high cost, high reaction temperature, low yield, tedious aftertreatment, long production cycle and the like, the invention provides a simple and...

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Bibliographische Detailangaben
Hauptverfasser: WU NUOYI, TIAN PING, LIN GUOQIANG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a preparation method of dexrazoxane. In allusion to various problems of a present dexrazoxane synthetic route, such as complexity, high cost, high reaction temperature, low yield, tedious aftertreatment, long production cycle and the like, the invention provides a simple and efficient preparation method of dexrazoxane. Starting from (S)-1,2- diaminopropane hydrochloride or (S)-1,2-diaminopropane, only two steps are required to obtain a crude product dexrazoxane with the highest purity of 99.46%; and simple recrystallization is carried out to obtain a pure product with purity of 99.96%. The method has advantages of simple operation and proper temperature. By the method, the cycle of synthetic process is shortened greatly. In addition, yield and purity of the product are also raised greatly.