Non-terminally-sterilized sterile four nacre-borneol-boric acid-borax eyedrop and preparation method thereof

The invention discloses a non-terminally-sterilized sterile four nacre-borneol-boric acid-borax eyedrop and a preparation method thereof. The non-terminally-sterilized sterile four nacre-borneol-boric acid-borax eyedrop contains a nacre powder extract, natural borneol, boric acid, borax and other auxiliary materials; the pH value of the eyedrop ranges from 7.0 to 7.8, and the osmotic pressure of the eyedrop is within 0.24-0.36Osmol/kg; the nacre powder extract is subjected to microfiltration and/or ultrafiltration in a class C clean area so that the content of microorganism can be reduced or complete sterile condition can be achieved, and the filtrate is preserved at a low temperature; in the preparation process, the technology of combined step-by-step sterilization and multistage sterile filtration is adopted, the adopted auxiliary materials are dissolved in water for injection which is heated to boil, the nacre powder extract is added to the obtained accessory solution, stirred and mixed evenly, and then st