Surface-functionalized micro/nano polymer hollow particle and preparation method thereof

The invention discloses a micro/nano polymer hollow particle and particularly relates to a surface-functionalized micro/nano polymer hollow particle and a preparation method thereof. The preparation method comprises the following steps of firstly preparing a soluble polymer template particle by virtue of a simple polymerization process, then initiating a polymerization reaction of methylene succinic anhydride, N-vinyl pyrrolidone and a crosslinking agent on the surface of the template particle to prepare a polymer particle with a core-shell structure, and dissolving the inner core in the core-shell particle by virtue of a good solvent for a template inner core to prepare the hollow polymer particle of which the wall has uniform thickness and the surface is provided with reactive groups. Since reactive functional groups are arranged on the inner and outer surfaces of the cavity of the hollow polymer particle, the particular active substances, drugs, biological molecules, tumor targeting agents, antibodies and