Antibody and use thereof
An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid fibrils or monomeric amyloid -proteins. According to the present invention, an antibody is provided that has a higher reactivity with...
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| creator | HOSHI MINAKO NODA MUNEHIRO HORIE SATOSHI SATO MICHIO NAITO KOJI HORII HAJIME IDENO SHOJI |
| description | An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid fibrils or monomeric amyloid -proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid -proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids. |
| format | Patent |
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According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid -proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.</description><language>chi ; eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TESTING</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141015&DB=EPODOC&CC=CN&NR=104098695A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141015&DB=EPODOC&CC=CN&NR=104098695A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HOSHI MINAKO</creatorcontrib><creatorcontrib>NODA MUNEHIRO</creatorcontrib><creatorcontrib>HORIE SATOSHI</creatorcontrib><creatorcontrib>SATO MICHIO</creatorcontrib><creatorcontrib>NAITO KOJI</creatorcontrib><creatorcontrib>HORII HAJIME</creatorcontrib><creatorcontrib>IDENO SHOJI</creatorcontrib><title>Antibody and use thereof</title><description>An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid fibrils or monomeric amyloid -proteins. 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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING |
| title | Antibody and use thereof |
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