Antibody and use thereof

An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid fibrils or monomeric amyloid -proteins. According to the present invention, an antibody is provided that has a higher reactivity with...

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Bibliographische Detailangaben
Hauptverfasser:	HOSHI MINAKO, NODA MUNEHIRO, HORIE SATOSHI, SATO MICHIO, NAITO KOJI, HORII HAJIME, IDENO SHOJI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid fibrils or monomeric amyloid -proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid -proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.