Bisindole compound and synthetic method thereof

Bisindole compound and synthetic method thereof

The invention relates to a bisindole compound and a synthetic method thereof. According to the invention, 2,2'-(3,3'-N-benzyl-3-1H-indolylpropionamide)phenyl methane, 2,2'-bis(3,3'-N- benzyl-3-1H-indolylpropionamide)p-nitrophenyl methane, 2,2'-bis(3,3'-N-benzyl-3-1H-ind...

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Hauptverfasser: SUN HUA, SONG BINBIN, WANG YIQIAN, DENG WANG, XIANG CEN, YANG YAO, WANG TIANJIAO, SHI BIAO, JIANG LEI, YU PENG
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to a bisindole compound and a synthetic method thereof. According to the invention, 2,2'-(3,3'-N-benzyl-3-1H-indolylpropionamide)phenyl methane, 2,2'-bis(3,3'-N- benzyl-3-1H-indolylpropionamide)p-nitrophenyl methane, 2,2'-bis(3,3'-N-benzyl-3-1H-indolylpropionamide)p-fluorophenyl methane and2,2'-bis(3,3'-N-benzyl-3-1H-indolylpropionamide)p-methoxyphenyl methane of which IC50 values are respectively 56.19mu m, 90.71mu m, 58.55mu m, 67.22mu m have a certain growth inhibition effect on human leukemia cells (K562) tumor cells, ad analysis results show that the benzene ring molecular structure of which the p-position is bonded with a weak electron-withdrawing group and the meta-position is bonded with an electron-donating group has good activity.