Medicine composition for preventing and treating migraine disease as well as preparation method and application of medicine composition

The invention belongs to the field of research and development of a traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for preventing and treating a migraine disease as well as preparation method and an application of the medicine composition. The traditional Chinese medicine composition is prepared from medicines screened based on a traditional Chinese medicine clinical experience formula, namely a radix angelicae formula and is obtained by ethanol extraction according to the radix angelicae formula and purification and enrichment of macroporous adsorption resin. Main components of the traditional Chinese medicine composition are coumarins, phenolic acids and phthalide. Pharmacological experiments prove that the traditional Chinese medicine composition can be used for increasing the content of 5-HT in plasma of nitroglycerin-induced migraine model rats and the content of NO in brains of the rats, and reducing the content of calcitonin gene-related peptides in