Water-soluble phloretin derivative and preparation method thereof

The invention discloses a water-soluble phloretin derivative and a preparation method thereof. The chemical name of the compound is 7-phloretin amine ethyl ether, and the compound is prepared by taking a polar aprotic solvent as a reaction medium, taking phloretin and 2-bromoethylamine hydrobromide as raw materials and taking anhydrous potassium carbonate or anhydrous sodium carbonate as a catalyst. The water solubility of the water-soluble phloretin derivative is improved by 430 times in comparison with that of the phloretin, and the water-soluble phloretin derivative has obvious anti-oxidation activity, tyrosinase-inhibiting activity and antibacterial activity. The scavenging capacity against DPPH free radicals is IC50 being 120.20 mu mol/L and the scavenging capacity against ABTS free radicals is IC50 being 200.34 mu mol/L; the inhibition activity against mushroom tyrosinase is IC50 being 50.20 mu mol/L; the MIC against Gram-positive Listeria monocytogenes and staphylococcus aureus is 90 mu g/ML respectively, and the MIC against Gram-negative Escherichia coli and pseudomonas fluorescens is 600 mu g/mL and 900 mu g/mL respectively. The 7-phloretin amine ethyl ether disclosed by the invention has broader application prospects in the field of preparing medicines, cosmetics, health products and food preservatives.