PH value-sensitive curcumin medicine carrying micelle (double chains) and preparation method of precursor thereof

The invention relates to a PH value-sensitive curcumin medicine carrying micelle (double chains) and a preparation method of a precursor thereof. A PH value-sensitive curcumin medicine carrying micelle (double chains) monomer has a chemical formula as follows: BI (MPEG-PLA-N)=Cur. Reaction raw materials comprise methoxy polyethylene glycol-polylactic acid (MPEG-PLA) which contains hydrazino at the tail end after modification, and curcumin of which the two ends are subjected to phenolic hydroxyl carbonylation, and the two raw materials are dissolved in a certain solvent according to a proper batching ratio to have a bonding reaction to form the PH value-sensitive curcumin micelle monomer. Compared with the prior art, the PH value-sensitive curcumin medicine carrying micelle has the advantages that a hydrazone bond is introduced into a conventional diblock polymer (MPEG-PLA) structure and then bonded with a hydrophobic drug curcumin, and the prepared amphiphilic polymer is self-assembled in a water solution to