Thiazoline derivatives with aza-indole framework as well as preparation method and application thereof

The invention provides thiazoline derivatives with an aza-indole framework as well as a preparation method and application thereof. The thiazoline derivatives are shown in the formula (I), formula (II), formula (III) or formula (IV), wherein R is alkyl or aryl with 1-12 carbon atoms. A compound prov...

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Bibliographische Detailangaben
Hauptverfasser:	FU BIN, MA HONGLI, ZHANG ZHENHUA, TAN ZHAOHAI, HOU XUHE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING
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Beschreibung
Zusammenfassung:	The invention provides thiazoline derivatives with an aza-indole framework as well as a preparation method and application thereof. The thiazoline derivatives are shown in the formula (I), formula (II), formula (III) or formula (IV), wherein R is alkyl or aryl with 1-12 carbon atoms. A compound provided by the invention is obtained by condensing corresponding acyl chloride with amino alcohol, and catalytically synthesizing P2S5 and other sulfur-containing catalysts under an alkaline condition. The plant potting activity testifies that the derivatives (compounds of CAU-FB series) can be used for inhibiting plant diseases caused by fungi; particularly CAU-FB-210 and CAU-FB-215 respectively have good inhibition effects on vegetable grey mould and corn rust diseases. An anti-tumor activity screening experiment testifies that CAU-FB-206 and CAU-FB-220 have very good inhibition effects on human hepatoma carcinoma cells and human breast carcinoma cell and have a potential application value on prevention and treatmen