Novel dual-layer composite bone tissue engineering scaffold and preparation method thereof

The invention relates to a novel dual-layer composite bone tissue engineering scaffold and a preparation method thereof. The dual-layer bone tissue engineering scaffold comprises an outer-layer bacterial cellulose membrane and an inner-layer PLGA/MWNTs electrostatic spinning porous scaffold. The syn...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG HUALIN, CAI MIAOLIN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a novel dual-layer composite bone tissue engineering scaffold and a preparation method thereof. The dual-layer bone tissue engineering scaffold comprises an outer-layer bacterial cellulose membrane and an inner-layer PLGA/MWNTs electrostatic spinning porous scaffold. The synthetic material PLGA, a natural ingredient bacterial cellulose and an inorganic ingredient multi-wall carbon nanotubes are compounded together to form the composite material by using a vacuum freeze drying process and a high-pressure electrostatic spinning method. The materials have complementary advantages, and an ideal dual-layer composite bone tissue engineering scaffold of PLGA/MWNTs/bacterial cellulose, which is excellent in performance and relatively cheap, is built. The dual-layer composite bone tissue engineering scaffold of the PLGA/MWNTs/bacterial cellulose provided by the invention is simple in preparation method, and mild in condition, has good cell biocompatibility, accords with the requirements of app