Doxofylline compound and pharmaceutical composition thereof

The invention belongs to the technical field of medicines, and in particular relates to a doxofylline compound and a pharmaceutical composition thereof. A molecular formula of the doxofylline compound is represented in C11H14N4O4.0.5H2O, wherein the compound is shown as drawing 1 of an X-ray powder...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHANG JIWEN, ZHU YUQING, ZHONG YUCAI, HOU SHANBO
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention belongs to the technical field of medicines, and in particular relates to a doxofylline compound and a pharmaceutical composition thereof. A molecular formula of the doxofylline compound is represented in C11H14N4O4.0.5H2O, wherein the compound is shown as drawing 1 of an X-ray powder diffraction spectrogram obtained through Cu-K alpha ray measurement. The doxofylline compound disclosed by the invention is a new crystal structure of a doxofylline hemihydrate different from the prior art; through a pharmacodynamic test, the inventor pleasantly discovers that the doxofylline hemihydrate of the new crystal structure is more excellent in bioavailability; a doxofylline injection solution prepared from the new crystal structure is slight in change in insoluble particle after being matched with a compatible injection solution.