Synthesis method of oxetanone
The invention discloses a synthesis method of oxetanone. The method comprises the steps: in an organic solvent and in the presence of a catalyst, a halide and an alkali, utilizing an oxidant to oxidize oxetanol, and then separating and purifying to obtain oxetanone. The method adopts the organic oxi...
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Zusammenfassung: | The invention discloses a synthesis method of oxetanone. The method comprises the steps: in an organic solvent and in the presence of a catalyst, a halide and an alkali, utilizing an oxidant to oxidize oxetanol, and then separating and purifying to obtain oxetanone. The method adopts the organic oxidation system for oxidation production of oxetanone for the first time, is cheap in adopted materials and simple in operation, avoids use of methyl azide, butyl lithium, or 1,3-dichloroacetone and other dangerous chemicals, enables the synthesis method of oxetanone to be safely amplified, and can be produced in large scale; the method is friendly to the environment and avoids use of phosphorus pentoxide and other reagents, so that the process meets the requirements of environmental protection; and moreover, the method increases the reaction yield which is increased from 50% to 80% or more, thereby greatly reducing the production cost, and being in favor of further application and development of oxetanone in organic chemistry and biological medicines. |
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