Reconfigurable leak testing system

A reconfigurable leak testing system is provided that includes a leak testing station and at least one off-shuttle cart removably attachable to the leak testing station. A fixture cartridge is translatable between the off-shuttle cart and the leak testing station. The fixture cartridge is configured to selectively couple with the leak testing station. The fixture cartridge includes an upper fixture, a lower fixture, and an actuatable testing feature. The fixture cartridge is configured to receive a part between the upper fixture and lower fixture. The actuatable testing feature is configured to contact the part. A closed volume is defined at least partially by the actuatable testing feature and the part.