5-arylselenobenzimidazole compound and application thereof

The invention belongs to the technical field of medicine and relates to a 5-arylselenobenzimidazole compound and application thereof, specifically to the compound and application of the compound as a tumor cell proliferation inhibitor in preparation of antineoplastic drugs. The objective of the inve...

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Bibliographische Detailangaben
Hauptverfasser:	WU YINGLIANG, HAN CHUNMING, ZUO DAIYING, QI HUAN, WEN ZHIYONG, LI FUQING, ZHANG MINGLIANG, CAI LONG, ZHANG WEIGE, ZHAI MINAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention belongs to the technical field of medicine and relates to a 5-arylselenobenzimidazole compound and application thereof, specifically to the compound and application of the compound as a tumor cell proliferation inhibitor in preparation of antineoplastic drugs. The objective of the invention is to design and synthesize an analogue of Combretastatin A-4 with good antineoplastic activity, i.e., the 5-arylselenobenzimidazole compound. The synthesized compound presents good results in in-vitro and in-vivo antineoplastic activity tests.