Solid dispersion formulations and methods of use thereof

The present invention relates to formulations and methods for increasing the bioavailability of 1- (4-benzhydrylpiperazin-l-yl)-3,3-diphenylpropan-l-one, l-(3,3-diphenylpropanoyl) piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix...

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Bibliographische Detailangaben
Hauptverfasser:	CREW MARSHALL D, SMITHEY DANIEL T, HARIANAWALA ABIZER, PADVAL MAHESH V, GAUTSCHI JEFF T
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR SHAPING OR JOINING OF PLASTICS TRANSPORTING TRAPPING WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Beschreibung
Zusammenfassung:	The present invention relates to formulations and methods for increasing the bioavailability of 1- (4-benzhydrylpiperazin-l-yl)-3,3-diphenylpropan-l-one, l-(3,3-diphenylpropanoyl) piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.