Handheld device for electrophysiological analysis

The invention relates to a handheld device for analysis of electrophysiological properties of a cellular membrane ion channel in an ion channel containing lipid cellular membrane. The handheld device comprises a handheld body with a pump and an electronic controller, and a disposable pipette tip com...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BYRNE NICHOLAS, MATHES CHRISTOPHER, HENNEKE JENS, KUTCHINSKY JONATAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a handheld device for analysis of electrophysiological properties of a cellular membrane ion channel in an ion channel containing lipid cellular membrane. The handheld device comprises a handheld body with a pump and an electronic controller, and a disposable pipette tip comprising a pathway for fluid, said pathway connecting an open end of the pipette tip to an analysis substrate comprised in the pipette tip. The substrate is adapted to transmit an electrical current through the ion channel in said ion channel-containing lipid cellular membrane, when said lipid cellular membrane is held at a predetermined site of the substrate, e.g. for patch clamp analysis. The handheld body and the disposable pipette tip are configured to releasably attach the pipette tip to the body, to provide a hydraulic connection between the pump of the handheld body and said pathway, and to provide an electric connection between the electronic controller and at least one of said electrodes of the substrate. T