Combretastatin amino sugar conjugate and preparation method and medical appliance thereof

The invention relates to the field of medical chemistry, in particular to a Combretastatin (A-4, CA-4) amino sugar conjugate, and a preparation method and tumor blood vessel inhibition thereof. The Combretastatin amino sugar conjugate is good in water solubility. Pharmacology experiments show that t...

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Bibliographische Detailangaben
Hauptverfasser:	TU ZHEWEI, SI CHONGJING, LIU KUN, HE GUANGWEI, HE SHUYING, SUN JING, TANG YAN, XU YUNGEN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The invention relates to the field of medical chemistry, in particular to a Combretastatin (A-4, CA-4) amino sugar conjugate, and a preparation method and tumor blood vessel inhibition thereof. The Combretastatin amino sugar conjugate is good in water solubility. Pharmacology experiments show that the compound is high in inhibition of human umbilical vascular endothelial cell proliferation and good in inhibition of mice tumor cells. Therefore, the compound of formula I and the crystal-water-containing compound thereof can be used for treating various diseases related to angiogenesis, and the diseases include various cancers and chronic inflammation and other blood vessel originated diseases.