Improved-type human coagulation factor FVII-Fc fusion protein as well as preparation method and application thereof

Disclosed are a recombinant fusion protein of human blood coagulation factor FVII-Fc, preparation method therefor and use thereof. The fusion protein comprises a human FVII, flexible peptide linker, and IgG2 Fc variant sequentially from the N-terminal to the C-terminal. The Fc variant has on lytic a...

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Hauptverfasser: LIU CHANGFU, SUN JIANYU, ZHOU RUOYUN, FENG WEI, SUN NAICHAO, LI QIANG, WU CUI
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed are a recombinant fusion protein of human blood coagulation factor FVII-Fc, preparation method therefor and use thereof. The fusion protein comprises a human FVII, flexible peptide linker, and IgG2 Fc variant sequentially from the N-terminal to the C-terminal. The Fc variant has on lytic activity, and shows minimal Fc-mediated adverse side-effects. The fusion protein has a bioactivity similar to or higher than that of human FVII and a greatly prolonged plasma half-life, thereby improving the pharmacokinetics and pharmaceutical effect.