Refining method of alanyl-glutamine crude drug

The invention relates to a refining method of an alanyl-glutamine crude drug. The method comprises the following processes: adding an alanyl-glutamine crude product to water, stirring until the alanyl-glutamine crude product is completely dissolved; adding alkali to adjust the pH value, adding activ...

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Bibliographische Detailangaben
Hauptverfasser: HUANG GUOYING, LIU MINGMING, SONG CAIXIANG, LU YUN, LIU XUGUI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a refining method of an alanyl-glutamine crude drug. The method comprises the following processes: adding an alanyl-glutamine crude product to water, stirring until the alanyl-glutamine crude product is completely dissolved; adding alkali to adjust the pH value, adding active carbon, stirring for realizing absorption; filtering and decolorizing to obtain clear material liquid, then adding a polar solvent, crystallizing and filtering; and drying to obtain an alanyl-glutamine refined product. By adopting the refining method, alanyl-glutamine impurities and the content of bacterial endotoxin are effectively controlled; the target of intravenous administration is achieved; and the safety of alanyl-glutamine intravenous preparations is also improved.