Serum metabonomic method for screening biomarkers of transgenic animal

The invention relates to a serum metabonomic method for screening biomarkers of a transgenic animal. The serum metabonomic method comprises the following steps of: analyzing serums of a normal animal and the transgenic animal to obtain a metabolic fingerprint spectrum by adopting an ultra-high performance liquid chromatography-mass spectrometry technology; analyzing and comparing the difference between metabolic fingerprint spectrums of the normal animal and the transgenic animal by adopting a multivariate statistical analysis method; and screening potential biomarkers of the transgenic animal. According to the serum metabonomic method, the variation condition of metabolite of the transgenic animal are more comprehensively and synthetically embodied; and the serum metabonomic method is suitable for screening of biomarkers of transgenic animals.