Preparation method for idebenone microcapsule through ultrasonic inclusion by beta-cyclodextrin

The invention discloses a preparation method for an idebenone microcapsule through ultrasonic inclusion by beta-cyclodextrin. The preparation method comprises the following steps: dissolving beta-cyclodextrin in distilled water to prepare a saturated solution, heating the saturated solution of beta-...

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Bibliographische Detailangaben
Hauptverfasser: CHENG CHUANSHEN, LIANG JUAN, CHEN YIPING, ZHU JIELIAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a preparation method for an idebenone microcapsule through ultrasonic inclusion by beta-cyclodextrin. The preparation method comprises the following steps: dissolving beta-cyclodextrin in distilled water to prepare a saturated solution, heating the saturated solution of beta-cyclodextrin to a temperature of 30 to 80 DEG C in a water bath and carrying out isothermal stirring for 15 to 50 min; adding idebenone under the condition of isothermal stirring, continuing stirring to realize uniform mixing so as to obtain a mixed solution and subjecting the mixed solution to ultrasonic inclusion so as to obtain a beta-cyclodextrin-idebenone inclusion solution; and standing the beta-cyclodextrin-idebenone inclusion solution at a temperature of 0 to 8 DEG C for 24 h, carrying out pumping filtration and drying to obtain solid powder, grinding the solid powder into fine powder and carrying out sieving so as to obtain the beta-cyclodextrin-idebenone microcapsule. The preparation method provided by th