Synthetic method of 3-aminomethyl-isoxazole hydrochloride
The invention discloses a synthetic method of 3-aminomethyl-isoxazole hydrochloride. The synthetic method comprises the steps that with aluminium chloride as a catalyst, chloroacetyl chloride reacts with acetylene to obtain 2,4-dichloro-2-methyl vinyl ketone, then the 2,4-dichloro-2-methyl vinyl ket...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention discloses a synthetic method of 3-aminomethyl-isoxazole hydrochloride. The synthetic method comprises the steps that with aluminium chloride as a catalyst, chloroacetyl chloride reacts with acetylene to obtain 2,4-dichloro-2-methyl vinyl ketone, then the 2,4-dichloro-2-methyl vinyl ketone and hydroxylamine hydrochloride carry out reflux ring closure in methanol to obtain 3-chloromethyl-isoxazole, then the 3-chloromethyl-isoxazole reacts with NH(Boc)2 in acetonitrile to obtain a key intermediate bi-Boc aminomethyl-isoxazole, and finally Boc is removed in a hydrochloric acid-methanol solution to obtain the target product 3-aminomethyl-isoxazole hydrochloride. The method is mild and simple in reaction conditions, low in cost, high in yield, simple and convenient to operate and suitable for industrial production. |
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