Monohydrate crystal form, pharmaceutical composition and application thereof, and preparation technology

Describe is a crystalline form of (1 R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quina-zolin-4(3H)-one that is Form III and that is suitable for use in treating and/or preventing a microbial or fungal infection, and/or Chagas disease, in a mammal. Furt...

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Bibliographische Detailangaben
Hauptverfasser:	SERRA ANNA ROIG, GRAU ELIES MOLINS, MEYER KEVIN, ORPI JAVIER BARTROLI, PAREDES ANTONIO CANOVAS, LORIMER KEITH
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Describe is a crystalline form of (1 R,2R)-7-chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quina-zolin-4(3H)-one that is Form III and that is suitable for use in treating and/or preventing a microbial or fungal infection, and/or Chagas disease, in a mammal. Further described are pharmaceutical compositions comprising an effective amount of the crystalline form and a pharmaceutical-ly acceptable carrier