Method for preparing tegafur, gimeracil and oteracil potassium capsules

The invention relates to a method for preparing tegafur, gimeracil and oteracil potassium capsules. The method comprises the steps of dissolving tegafur in methanol, dissolving gimeracil in a hydrochloric acid solution, dissolving oteracil potassium in a sodium hydroxide solution, rapidly mixing the three solutions, rapidly adding microcrystalline cellulose and stirring, slowly cooling to about 4 DEG C at the same time to obtain nanoscale drug adhered to the microcrystalline cellulose, drying drug-containing particles, adding a lubricant into the dry particles, uniformly mixing and encapsulating. According to the invention, the technologies of acid-base neutralization and nanometer crystallization are creatively utilized to prepare nanoscale tegafur, gimeracil and oteracil potassium, so that the drug dissolution rate is greatly increased.