Curcumin dicaprate suspension injection and preparation method and application thereof

The invention discloses curcumin dicaprate and a derivative nano suspension agent, a preparation method of freeze-dried powder thereof and an application in the treatment of depression and tumor. A surfactant serves as a main pharmaceutical adjunct, particularly poloxamer, and curcumin dicaprate nan...

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Bibliographische Detailangaben
Hauptverfasser: WEI XIAOLAN, YAO GUANGYIN, QUAN LIHUI, LIAO YONGHONG, LIU CHUNYU, HAN YINGRUI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses curcumin dicaprate and a derivative nano suspension agent, a preparation method of freeze-dried powder thereof and an application in the treatment of depression and tumor. A surfactant serves as a main pharmaceutical adjunct, particularly poloxamer, and curcumin dicaprate nano granulation is successfully realized by employing the wet grinding combined freeze drying technology. The curcumin dicaprate is prepared into a pharmaceutically acceptable oil diluent, and the reconstructed curcumin dicaprate and derivative nano suspension agent can be prepared into a nano suspension agent for injection with the particle size of about 500nm. The nano suspension agent consists of the following components: curcumin dicaprate and/or derivatives thereof and the surfactant. The nano suspension agent preparation can be applied to treating depression and tumors. The nano suspension agent preparation is simple in composition, high in stability, high in needle penetration, economic and reliable in prepara