Reworking method of cefpirome sulfate

The invention discloses a reworking method of cefpirome sulfate. The reworking method comprises the following steps of: 1) dissolving the cefpirome sulfate to be reworked in a certain amount of water; 2) dripping an organic base for dissolution, regulating the PH value to 4.0-8.0, and setting the re...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LENG XIONGJUN, WEN XIONGFEI, LV DEXIN, ZHOU ZIJIN, ZENG RUNBAO
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention discloses a reworking method of cefpirome sulfate. The reworking method comprises the following steps of: 1) dissolving the cefpirome sulfate to be reworked in a certain amount of water; 2) dripping an organic base for dissolution, regulating the PH value to 4.0-8.0, and setting the reaction temperature at 0 DEG C-30 DEG C; 3) enabling the solution after dissolution to pass through a column loaded with an adsorbent, and collecting filtrate; 4) adding activated carbon into the filtrate, performing decolorization reaction for 30min, and filtering; 5) regulating the PH value of the filtrate after decolorization to 1.2-2.4; 6) adding a quantitative crystallizing agent into the filtrate for crystallization, controlling the crystallization temperature at 0 DEG C-30 DEG C, and stirring for 2-4h till the end of reaction; 7) filtering, and washing with one solution or a mixed solution of acetone and alcohol; and 8) drying at the temperature of 45 DEG C-55 DEG C to obtain the cefpirome sulfate. According