Synthesis method of m-phenyl formyl phenylacetic acid

The invention discloses a synthesis method of m-phenyl formyl phenylacetic acid, belonging to the technical fields of medicine and chemical industries. The m-phenyl formyl phenylacetic acid is an important medical intermediate. According to the synthesis method, a simple and practicable reaction for...

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Hauptverfasser: MAO YU, ZHANG RENYAN, DING JUPING, YU QIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a synthesis method of m-phenyl formyl phenylacetic acid, belonging to the technical fields of medicine and chemical industries. The m-phenyl formyl phenylacetic acid is an important medical intermediate. According to the synthesis method, a simple and practicable reaction for substituting halogens by a cyano group is obtained via exploration and practice; simultaneously, the concentration range of sulphuric acid used during hydrolysis for the cyano group in 3-benzoyl phenyl acetonitrile and the proper temperature of the reaction are determined, thus obtaining the synthesised m-phenyl formyl phenylacetic acid. The synthesis process is moderate in reaction conditions, simple in after-treatment and easy to industrialize.