Methotrexate-loaded magnetosome drug carrier and preparation method thereof

The invention provides a methotrexate-loaded magnetosome drug carrier and a preparation method thereof. Methotrexate is crosslinked on a biological film of a magnetosome through genipin and the magnetosome is extracted from magnetotactic bacteria. The preparation method comprises the following steps of: 10, dispersing magnetosome particles after being subjected to purifying and freeze drying in a solvent and adding a methotrexate solution; 20, ultrasonically dispersing and fully mixing the mixed liquor obtained in the step 10; 30, adding a genipin solution and continuing the ultrasonic dispersion to be uniform; and 40, putting the mixed liquor obtained in the step 30 in a shaker to carry out crosslinking and obtaining the methotrexate-loaded magnetosome drug carrier after crosslinking saturation. According to the invention, a natural magnetic targeting antitumor drug delivering system can be constructed; and meanwhile, the utilization ratio of methotrexate can be increased and the toxic and side effects of me