Preparation method and application of acid or active ester of polyethylene glycol with tail end connected with proline

The invention discloses a preparation method and application of acid or active ester of polyethylene glycol with the tail end connected with proline, belonging to the field of medicine. The hydrolytic half-time period of the polymer active ester in water is 10.9 minutes and has the ideal activity of...

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Bibliographische Detailangaben
Hauptverfasser:	LUO YU, XIONG YUCHUN, LI ZHICHENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a preparation method and application of acid or active ester of polyethylene glycol with the tail end connected with proline, belonging to the field of medicine. The hydrolytic half-time period of the polymer active ester in water is 10.9 minutes and has the ideal activity of reacting with the amino of bioactive substances. The structural formula is R1-(OCH2CH2)n-O-R2, wherein n is equal to 43-680; the R1 can be CH3- or R2; the structure of the R2 is shown in the specification; and the R3 can be H- or -N-succinimide.