Preparation method of dexrazoxane

The invention relates to the field of medicament synthesis, in particular relates the synthetic field of anti-tumor medicaments, and more particularly relates to a preparation method of dexrazoxane. Aiming at the problems that the current synthetic route of dexrazoxane is complex, the cost is high,...

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Hauptverfasser: DU YOUGUO, ZHAO XIAOWEI, YANG ZHANXIONG, CHEN XIANGFENG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to the field of medicament synthesis, in particular relates the synthetic field of anti-tumor medicaments, and more particularly relates to a preparation method of dexrazoxane. Aiming at the problems that the current synthetic route of dexrazoxane is complex, the cost is high, the post treatment steps are tedious and the product purity and product yield cannot be improved, the invention provides the preparation method of dexrazoxane. (S)-1,2-diaminopropane-tetraacetate can be obtained through only one step, thus not only is the production cycle shortened, but also the production cost is reduced. Besides, according to the technical scheme disclosed by the invention, reaction conditions such as high temperature, long cycle and high toxicity are avoided, so that the synthetic process is more environment-friendly, and is more suitable for being used in current pharmaceutical industry.