Preparation method of hydrocortisone acetate

The invention discloses a preparation method of hydrocortisone acetate, belonging to the field of chemical pharmacy. The preparation method comprises the following steps: by using an intermediate Pu's oxide in the traditional cortisone acetate synthesis technique as a raw material, sequentially carrying out ketalation reaction, reduction reaction, hydrolysis reaction, iodine reaction and acetylation reaction under certain conditions to obtain the product hydrocortisone acetate. The preparation method of hydrocortisone acetate has the advantages of accessible raw materials and common auxiliary materials, and does not need some toxic, virulent and cancerigenic reagents in the original technique. The invention is environment-friendly and effective; the product has both high quality and yield; and the HPLC (high performance liquid chromatography) content is up to higher than 98.5%, and the yield is up to higher than 80%.