Coumarin triadimenol, and preparation method and application thereof
The invention discloses coumarin triadimenol shown in a structural formula I and a preparation method thereof. The preparation method comprises the following step: under the catalytic effect of inorganic base, reacting 5,7-di((epoxyethyl-2-)methoxy)-4-methyl coumarin and 1H-1,2,4-triazole at 60-80 D...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | WEN QINMEI PENG SHENMEI CUI SHENGFENG GULILVDAMM ZHOU CHENGHE LI QINGXIA |
| description | The invention discloses coumarin triadimenol shown in a structural formula I and a preparation method thereof. The preparation method comprises the following step: under the catalytic effect of inorganic base, reacting 5,7-di((epoxyethyl-2-)methoxy)-4-methyl coumarin and 1H-1,2,4-triazole at 60-80 DEG C in an organic solvent while stirring. In-vitro antimicrobial activity detection discovers that the compound has a certain activity inhibition effect on gram positive bacteria (Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Micrococcus luteus and Bacillus subtilis), gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus proteus and Salmonella typhosa) and fungi (Candida albicans and Candida krusei). The compound can be used for preparing antibacterial and/or antifungal drugs. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN102796087A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN102796087A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN102796087A3</originalsourceid><addsrcrecordid>eNrjZHBxzi_NTSzKzFMoKcpMTMnMTc3Lz9FRSMxLUSgoSi1ILEosyczPU8hNLcnITwELJxYU5GQmQ4RLMlKLUvPTeBhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoYGRuaWZgYW5ozExagDaJzMq</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Coumarin triadimenol, and preparation method and application thereof</title><source>esp@cenet</source><creator>WEN QINMEI ; PENG SHENMEI ; CUI SHENGFENG ; GULILVDAMM ; ZHOU CHENGHE ; LI QINGXIA</creator><creatorcontrib>WEN QINMEI ; PENG SHENMEI ; CUI SHENGFENG ; GULILVDAMM ; ZHOU CHENGHE ; LI QINGXIA</creatorcontrib><description>The invention discloses coumarin triadimenol shown in a structural formula I and a preparation method thereof. The preparation method comprises the following step: under the catalytic effect of inorganic base, reacting 5,7-di((epoxyethyl-2-)methoxy)-4-methyl coumarin and 1H-1,2,4-triazole at 60-80 DEG C in an organic solvent while stirring. In-vitro antimicrobial activity detection discovers that the compound has a certain activity inhibition effect on gram positive bacteria (Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Micrococcus luteus and Bacillus subtilis), gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus proteus and Salmonella typhosa) and fungi (Candida albicans and Candida krusei). The compound can be used for preparing antibacterial and/or antifungal drugs.</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121128&DB=EPODOC&CC=CN&NR=102796087A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121128&DB=EPODOC&CC=CN&NR=102796087A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WEN QINMEI</creatorcontrib><creatorcontrib>PENG SHENMEI</creatorcontrib><creatorcontrib>CUI SHENGFENG</creatorcontrib><creatorcontrib>GULILVDAMM</creatorcontrib><creatorcontrib>ZHOU CHENGHE</creatorcontrib><creatorcontrib>LI QINGXIA</creatorcontrib><title>Coumarin triadimenol, and preparation method and application thereof</title><description>The invention discloses coumarin triadimenol shown in a structural formula I and a preparation method thereof. The preparation method comprises the following step: under the catalytic effect of inorganic base, reacting 5,7-di((epoxyethyl-2-)methoxy)-4-methyl coumarin and 1H-1,2,4-triazole at 60-80 DEG C in an organic solvent while stirring. In-vitro antimicrobial activity detection discovers that the compound has a certain activity inhibition effect on gram positive bacteria (Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Micrococcus luteus and Bacillus subtilis), gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus proteus and Salmonella typhosa) and fungi (Candida albicans and Candida krusei). The compound can be used for preparing antibacterial and/or antifungal drugs.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBxzi_NTSzKzFMoKcpMTMnMTc3Lz9FRSMxLUSgoSi1ILEosyczPU8hNLcnITwELJxYU5GQmQ4RLMlKLUvPTeBhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvLOfoYGRuaWZgYW5ozExagDaJzMq</recordid><startdate>20121128</startdate><enddate>20121128</enddate><creator>WEN QINMEI</creator><creator>PENG SHENMEI</creator><creator>CUI SHENGFENG</creator><creator>GULILVDAMM</creator><creator>ZHOU CHENGHE</creator><creator>LI QINGXIA</creator><scope>EVB</scope></search><sort><creationdate>20121128</creationdate><title>Coumarin triadimenol, and preparation method and application thereof</title><author>WEN QINMEI ; PENG SHENMEI ; CUI SHENGFENG ; GULILVDAMM ; ZHOU CHENGHE ; LI QINGXIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN102796087A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2012</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WEN QINMEI</creatorcontrib><creatorcontrib>PENG SHENMEI</creatorcontrib><creatorcontrib>CUI SHENGFENG</creatorcontrib><creatorcontrib>GULILVDAMM</creatorcontrib><creatorcontrib>ZHOU CHENGHE</creatorcontrib><creatorcontrib>LI QINGXIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WEN QINMEI</au><au>PENG SHENMEI</au><au>CUI SHENGFENG</au><au>GULILVDAMM</au><au>ZHOU CHENGHE</au><au>LI QINGXIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Coumarin triadimenol, and preparation method and application thereof</title><date>2012-11-28</date><risdate>2012</risdate><abstract>The invention discloses coumarin triadimenol shown in a structural formula I and a preparation method thereof. The preparation method comprises the following step: under the catalytic effect of inorganic base, reacting 5,7-di((epoxyethyl-2-)methoxy)-4-methyl coumarin and 1H-1,2,4-triazole at 60-80 DEG C in an organic solvent while stirring. In-vitro antimicrobial activity detection discovers that the compound has a certain activity inhibition effect on gram positive bacteria (Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Micrococcus luteus and Bacillus subtilis), gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus proteus and Salmonella typhosa) and fungi (Candida albicans and Candida krusei). The compound can be used for preparing antibacterial and/or antifungal drugs.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN102796087A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Coumarin triadimenol, and preparation method and application thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T07%3A10%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=WEN%20QINMEI&rft.date=2012-11-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN102796087A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |