Coumarin triadimenol, and preparation method and application thereof

The invention discloses coumarin triadimenol shown in a structural formula I and a preparation method thereof. The preparation method comprises the following step: under the catalytic effect of inorganic base, reacting 5,7-di((epoxyethyl-2-)methoxy)-4-methyl coumarin and 1H-1,2,4-triazole at 60-80 D...

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Bibliographische Detailangaben
Hauptverfasser:	WEN QINMEI, PENG SHENMEI, CUI SHENGFENG, GULILVDAMM, ZHOU CHENGHE, LI QINGXIA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses coumarin triadimenol shown in a structural formula I and a preparation method thereof. The preparation method comprises the following step: under the catalytic effect of inorganic base, reacting 5,7-di((epoxyethyl-2-)methoxy)-4-methyl coumarin and 1H-1,2,4-triazole at 60-80 DEG C in an organic solvent while stirring. In-vitro antimicrobial activity detection discovers that the compound has a certain activity inhibition effect on gram positive bacteria (Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Micrococcus luteus and Bacillus subtilis), gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus proteus and Salmonella typhosa) and fungi (Candida albicans and Candida krusei). The compound can be used for preparing antibacterial and/or antifungal drugs.