Synthesis method of poly-benzyl L-glutamate/ethyl polyphosphate block copolymer

The invention relates to a synthesis method of a poly-benzyl L-glutamate/ethyl polyphosphate block copolymer. The technical scheme is as follows: the synthesis method comprises the following steps: respectively dissolving moderate amino-terminated ethyl polyphosphate and benzyl L-glutamate amino acid anhydride into CH2Cl2, mixing, stirring and reacting at room temperature for 12-48 hours, after reaction is completed, dropping a product into diethyl ether to precipitate, standing at 2 DEG C for 12-18 hours, filtering, precipitating at 30 DEG C, and drying in vacuum to obtain a target product. Through the invention, the amphiphilic poly-benzyl L-glutamate/ethyl polyphosphate block copolymer is obtained, a micelle with a hydrophobic core and a hydrophilic shell is self-assembled in aqueous solution, a hydrophobic medicine molecule is assembled in the hydrophobic core, the circulating time of the medicine in the blood is improved, and the poly-benzyl L-glutamate/ethyl polyphosphate block copolymer has good applic