Recombinant chromatin modified albumin 1A, as well as coding gene and application thereof

The invention discloses a recombinant chromatin modified albumin 1A, as well as a coding gene of and an application of the recombinant chromatin modified albumin 1A, wherein the recombinant chromatin modified albumin 1A comprises chromatin modified albumin 1A, the C end of the chromatin modified alb...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN YING, XU PANSHENG, LI FENG, CHEN GUOCAN, ZHANG LIJIANG, YOU ZHENQIANG, ZHOU GUOLIANG, XUAN YAOXIAN, XIN YANFEI, YANG HONGZHONG, CHEN YUNXIANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a recombinant chromatin modified albumin 1A, as well as a coding gene of and an application of the recombinant chromatin modified albumin 1A, wherein the recombinant chromatin modified albumin 1A comprises chromatin modified albumin 1A, the C end of the chromatin modified albumin 1A is connected with His-Tag, the N end of the chromatin modified albumin 1A is connected with a PTD (protein transduction domain) sequence, the amino acid sequence of the PTD sequence is YGRKKRRQRRR, and the amino acid sequence of the recombinant chromatin modified albumin 1A is shown as SEQ ID NO.2. According to the recombinant chromatin modified albumin 1A, an HIS-Tag tag is guided into wild type Chmp1A, so that the structure of the Chmp1A can not be changed, and can be easily purified through a Ni-NTA (nitrilotriacetic acid) Argarose albumen purifying system. The PTD sequence is guided into the wide type Chmp1A, so that the Chmp1A can effectively enter into tumor cell under the guide of the PTD, and the an