Method for preparing and purifying Valganciclovir hydrochloride
The invention provides a method for preparing and purifying Valganciclovir hydrochloride, characterized by using ganciclovir as a raw material and carrying out N,O triphenylmethyl protection, esterification, deprotection, salt transformation and recrystallization to obtain Valganciclovir hydrochlori...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention provides a method for preparing and purifying Valganciclovir hydrochloride, characterized by using ganciclovir as a raw material and carrying out N,O triphenylmethyl protection, esterification, deprotection, salt transformation and recrystallization to obtain Valganciclovir hydrochloride. According to the invention, by using mixed anhydride method and avoiding using DCC, the posttreatment is simple; by using BOC protection to replace the CBZ protection used in the prior art, the reaction procedures are simplified, and the need for using noble metal Pd is avoided. The invention is suitable for industrial production. |
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