Method for preparing 4-[(4,6-dichloro-2-pyrimidyl) amino] cyanophenyl
The invention discloses a method for preparing a critical chloro intermediate of 4-[(4,6-dichloro-2-pyrimidyl) amino] cyanophenyl (IV) of etravirine by taking 4-aminobenzamide as starting raw materials. The method has the advantages that the 4-aminobenzamide is used as the starting raw materials, th...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention discloses a method for preparing a critical chloro intermediate of 4-[(4,6-dichloro-2-pyrimidyl) amino] cyanophenyl (IV) of etravirine by taking 4-aminobenzamide as starting raw materials. The method has the advantages that the 4-aminobenzamide is used as the starting raw materials, the operation is safe, the cost of the raw materials is low, and no toxicity exists; and the product purity is good, and the yield in each step is higher than 80 percent. |
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