Doripenem intermediate compound, preparation method and application of doripenem intermediate compound and preparation method for doripenem

Doripenem intermediate compound, preparation method and application of doripenem intermediate compound and preparation method for doripenem

The invention provides a doripenem intermediate compound shown in formula (XIV), wherein PNB is p-nitrobenzyl and HX is acid; in addition, when HX is monobasic acid, n=1; when HX is polybasic acid, n=2. The invention also provides a method for preparation of the doripenem intermediate compound (XIV)...

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Hauptverfasser: ZHANG YANJUN, LV ZHILI, WU CONGQUAN, LONG LISONG, LU ZHAOQIANG, LI GUANGCHENG, DING CHENG, REN PENG
Format: Patent
Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator ZHANG YANJUN
LV ZHILI
WU CONGQUAN
LONG LISONG
LU ZHAOQIANG
LI GUANGCHENG
DING CHENG
REN PENG
description The invention provides a doripenem intermediate compound shown in formula (XIV), wherein PNB is p-nitrobenzyl and HX is acid; in addition, when HX is monobasic acid, n=1; when HX is polybasic acid, n=2. The invention also provides a method for preparation of the doripenem intermediate compound (XIV) and a method for preparation of doripenem (I) by the doripenem intermediate compound (XIV) in an easier way at low production cost for high yield. The new mono-protection doripenem intermediate compound provided by the invention contains only one protecting group, thereby lowering the difficulty and complexness of the following step of catalytic hydrogenation for deprotection. Therefore, the yield of catalytic hydrogenation reaction is increased, the production cost for final product is reduced, the operation is simple, and the compound is suitable for industrialized production.
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subjects CHEMISTRY
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METALLURGY
ORGANIC CHEMISTRY
title Doripenem intermediate compound, preparation method and application of doripenem intermediate compound and preparation method for doripenem
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