Plasma coupling structure microsphere for surface-enhanced Raman scattering (SERS) and manufacturing method thereof

The invention relates to a plasma coupling structure microsphere for surface-enhanced Raman scattering (SERS). By the plasma coupling structure microsphere, a magnetic microsphere serves as a kernel, and a metal cladding I, a nonmetallic isolating layer and a metal cladding II are formed outside the kernel one by one, wherein the metal cladding I or the metal cladding II has the thickness of 0 to 50nm; the nonmetallic isolating layer has the thickness of 0 to 100nm; and the plasma coupling structure microsphere has the particle size of 300 to 1,000nm and the specific saturation magnetization of 10 to 50emu/g. The plasma coupling structure microsphere is simple in manufacturing method and controllable in product structure, the obtained microsphere can be suitable for biological separation and detection, and when the microsphere is used for detecting a Raman-enhanced effect, the detection rate can reach 10 mol/L; and moreover, the plasma coupling structure microsphere is applied to the fields of photochemic