Purification production method of goserelin polypeptide
The invention discloses a purification method of goserelin, which comprises the following steps: performing gradient elution purification by a Source column and a reversed phase chromatographic column to obtain high-purity goserelin trifluoroacetate, then converting the goserelin trifluoroacetate in...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention discloses a purification method of goserelin, which comprises the following steps: performing gradient elution purification by a Source column and a reversed phase chromatographic column to obtain high-purity goserelin trifluoroacetate, then converting the goserelin trifluoroacetate into acetate through an anion exchange salt conversion method. The invention purifies goserelin by the combined purification method, has high purity and good yield, provides a process method suitable for large-scale goserelin purification, and reaches industrialization requirements. |
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