Method for removing/inactivating prion in glycoprotein

The invention discloses a method for removing/inactivating prion in glycoprotein. The method comprises one or a plurality of steps as follows: (a) filtering glycoprotein-containing solution with a microporous membrane; (b) filtering the glycoprotein-containing solution with a nano-filtration membran...

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Bibliographische Detailangaben
Hauptverfasser: GUO ZHAOYE, JI BIN, GAO XIAOLIANG, JI XIAOMING, HONG YUNHAI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a method for removing/inactivating prion in glycoprotein. The method comprises one or a plurality of steps as follows: (a) filtering glycoprotein-containing solution with a microporous membrane; (b) filtering the glycoprotein-containing solution with a nano-filtration membrane or an ultrafiltration membrane; and (c) carrying out anion exchange chromatography to the glycoprotein-containing solution, wherein the order of the steps can be randomly exchanged.