Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophob...
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| creator | VEMISHETTI PURUSHOTHAM KUCERA DAVID J PRASAD SIVA JOSYULA PATEL SUNIL S SHI ZHONGPING LIANG JING RIJHWANI SUSHIL K SINGH AMBARISH K BIEN JEFFREY T LEWIS CHARLES ZHOU MAOTANG X BANERJEE AMIT THOTTATHIL JOHN CHEN CHUNG-PIN H PATEL RAMESH N STOJANOVIC MILAN PENDRI YADAGIRI R CHAN YEUNG YU WANG SHAOPENG EVANS JEFFREY M POLNIASZEK RICHARD P KRONENTHAL DAVID R POWERS GERALD L KRISHNAMURTY DHILEEPKUMAR |
| description | The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising:
(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent. |
| format | Patent |
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(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150506&DB=EPODOC&CC=CN&NR=102675355B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150506&DB=EPODOC&CC=CN&NR=102675355B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VEMISHETTI PURUSHOTHAM</creatorcontrib><creatorcontrib>KUCERA DAVID J</creatorcontrib><creatorcontrib>PRASAD SIVA JOSYULA</creatorcontrib><creatorcontrib>PATEL SUNIL S</creatorcontrib><creatorcontrib>SHI ZHONGPING</creatorcontrib><creatorcontrib>LIANG JING</creatorcontrib><creatorcontrib>RIJHWANI SUSHIL K</creatorcontrib><creatorcontrib>SINGH AMBARISH K</creatorcontrib><creatorcontrib>BIEN JEFFREY T</creatorcontrib><creatorcontrib>LEWIS CHARLES</creatorcontrib><creatorcontrib>ZHOU MAOTANG X</creatorcontrib><creatorcontrib>BANERJEE AMIT</creatorcontrib><creatorcontrib>THOTTATHIL JOHN</creatorcontrib><creatorcontrib>CHEN CHUNG-PIN H</creatorcontrib><creatorcontrib>PATEL RAMESH N</creatorcontrib><creatorcontrib>STOJANOVIC MILAN</creatorcontrib><creatorcontrib>PENDRI YADAGIRI R</creatorcontrib><creatorcontrib>CHAN YEUNG YU</creatorcontrib><creatorcontrib>WANG SHAOPENG</creatorcontrib><creatorcontrib>EVANS JEFFREY M</creatorcontrib><creatorcontrib>POLNIASZEK RICHARD P</creatorcontrib><creatorcontrib>KRONENTHAL DAVID R</creatorcontrib><creatorcontrib>POWERS GERALD L</creatorcontrib><creatorcontrib>KRISHNAMURTY DHILEEPKUMAR</creatorcontrib><title>Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one</title><description>The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising:
(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjsEKgkAURd20iOofhlYKPUhNo21RtIqgdiLysqcOTDPDOEXzNf1qkn5Aq3sW93Dv2PucjSqpbVmlDNOGNBoua2YbYigtf3GDgmFN0rIsvIAfotANLmLW5-pGFoMcIsAHlwrCxQbuvHF3o2AD2Qp--HYQgz_gg2zjRNApPZGk0pVC6W7DiRzSI-hndwJSUJKm3qhC0dJsyIk3P-yvuyOQVgW1GsvOt8XuFC6jdJ3ESbLdxn-VvjA6Uf8</recordid><startdate>20150506</startdate><enddate>20150506</enddate><creator>VEMISHETTI PURUSHOTHAM</creator><creator>KUCERA DAVID J</creator><creator>PRASAD SIVA JOSYULA</creator><creator>PATEL SUNIL S</creator><creator>SHI ZHONGPING</creator><creator>LIANG JING</creator><creator>RIJHWANI SUSHIL K</creator><creator>SINGH AMBARISH K</creator><creator>BIEN JEFFREY T</creator><creator>LEWIS CHARLES</creator><creator>ZHOU MAOTANG X</creator><creator>BANERJEE AMIT</creator><creator>THOTTATHIL JOHN</creator><creator>CHEN CHUNG-PIN H</creator><creator>PATEL RAMESH N</creator><creator>STOJANOVIC MILAN</creator><creator>PENDRI YADAGIRI R</creator><creator>CHAN YEUNG YU</creator><creator>WANG SHAOPENG</creator><creator>EVANS JEFFREY M</creator><creator>POLNIASZEK RICHARD P</creator><creator>KRONENTHAL DAVID R</creator><creator>POWERS GERALD L</creator><creator>KRISHNAMURTY DHILEEPKUMAR</creator><scope>EVB</scope></search><sort><creationdate>20150506</creationdate><title>Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one</title><author>VEMISHETTI PURUSHOTHAM ; 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(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE |
| title | Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one |
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