Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophob...

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Hauptverfasser: VEMISHETTI PURUSHOTHAM, KUCERA DAVID J, PRASAD SIVA JOSYULA, PATEL SUNIL S, SHI ZHONGPING, LIANG JING, RIJHWANI SUSHIL K, SINGH AMBARISH K, BIEN JEFFREY T, LEWIS CHARLES, ZHOU MAOTANG X, BANERJEE AMIT, THOTTATHIL JOHN, CHEN CHUNG-PIN H, PATEL RAMESH N, STOJANOVIC MILAN, PENDRI YADAGIRI R, CHAN YEUNG YU, WANG SHAOPENG, EVANS JEFFREY M, POLNIASZEK RICHARD P, KRONENTHAL DAVID R, POWERS GERALD L, KRISHNAMURTY DHILEEPKUMAR
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove salt; and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.