Process for preparing pharmaceutical mirabilite oral liquid containing dimethyl silicone oil

The invention discloses a process for preparing pharmaceutical mirabilite oral liquid containing dimethyl silicone oil. The process comprises the following steps: filtering underground conveyed raw aqueous glauber salt with a filter and carrying out ion exchange refining and purifying on the raw aqu...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG DAMING, LIU WENLIANG, LONG XU, LIU ZEMIN, YONG JIANGUO, DU WENBIN, ZOU HUARONG, GOU XINGWU, LI HONGQING
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a process for preparing pharmaceutical mirabilite oral liquid containing dimethyl silicone oil. The process comprises the following steps: filtering underground conveyed raw aqueous glauber salt with a filter and carrying out ion exchange refining and purifying on the raw aqueous glauber salt to obtain refined aqueous glauber salt with content of metal ion impurities being3-5ppm, after sterilization with a two-stage microporous membrane cartridge filter, adding dimethyl silicone oil emulsion, adding 10-20wt% of anhydrous edible alcohol, 3-15wt% of pharmaceutical nonionic surfactant and 0.5-1.0wt% of potassium sorbate to sterile deionized water, adding 5-8wt% of pharmaceutical grade dimethyl silicone oil under the conditions of temperature of 70-90 DEG C and stirring at high speed of 2800-1500rpm, carrying out high-speed stirring for 15-45 minutes, cooling dimethyl silicone oil to normal temperature and inputting the refined mirabilite solution after dimethyl silicone oil is completely