Pyrazole and pyrazine diketone derivative and application thereof

The invention relates to a general formula (I) of a 5-substituent-2 (4-(non) substituted phenyl) prrazole [1, 5-a] pyrazine-4, 6 (5H, 7H)-diketone derivative, wherein R1 represents hydrogen, C1-4 alkyl, alkoxy, halogen and nitro; R2 represents C1-4 alkyl and one of C1-2-aryl group and aryl-. The synthesis method of the compound is that under the condition that potassium carbonate serves as an acid-binding agent, a 2-chlorine-N-benzyl (substituted phenethyl) acetamide derivative and 3-(non) substituted phenyl-1H-pyrazole-5-ethyl formate perform reflux reaction in acetonitrile to obtain the 5-substituent-2 (4-(non) substituted phenyl) prrazole [1, 5-a] pyrazine-4, 6 (5H, 7H)-diketone derivative. Proved through pharmacological experiments, the compound can restrain proliferation of human lung cancer H322 cells remarkably, and indicates that the compound has significant meaning in preparation of antineoplastic drugs.