Method for preparing 1-(4,5-dihydrothiazol-2-yl)-3-hydroxyl-azetidine hydrochloride

The invention provides a method for preparing 1-(4,5-dihydrothiazol-2-yl)-3- sulfydryl-azetidine hydrochloride. According to the method, a reaction solvent is single, namely methanol is present only and suitable for industrial recycle; reaction time with alkali is short and only several minutes, disulfide compound impurities are reduced and energy is saved; an isopropanol/tetrahydrofuran (IPA/THF) mixed solvent is used for recrystallization, a product can be quickly inserted from an oily matter to a solid, product purity is improved and industrial operation is facilitated; and the reaction yield is high and is over 80 percent and the product purity is over 98 percent. The method is easy and convenient to implement, and suitable for industrial production.