Shikonin derivative containing fluorine carboxylic acid ester and synthetic method and application thereof
The invention belongs to the technical field of chemical pharmacy, particularly relates to preparation of a derivative containing fluorine carboxylic acid ester and application of the derivative in tumor inhibition. The ester derivative is obtained by intriducing fluorocarboxylic acid in shikonin fr...
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| creator | HAORIQINBATU LIU HONGCHANG LIN HONGYAN SHI JING WANG XIAOMING KONG WENYAO YANG YONGHUA QI JINLIANG |
| description | The invention belongs to the technical field of chemical pharmacy, particularly relates to preparation of a derivative containing fluorine carboxylic acid ester and application of the derivative in tumor inhibition. The ester derivative is obtained by intriducing fluorocarboxylic acid in shikonin framework molecules through a synthetic method. An in-vitro antitumor activity study shows that the derivative containing the fluorocarboxylic acid has strong inhibition activity to tumor cell lines. |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Shikonin derivative containing fluorine carboxylic acid ester and synthetic method and application thereof |
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